An early rule-out pathway for myocardial infarction reduces length of stay and hospital admissionswithout increasing adverse cardiac events, according to late breaking results from the HiSTORIC trial presented at ESC Congress 2019 in Paris and published in Circulation. We interviewed principal investigator Nicholas Mills of the University of Edinburgh: “This is the first randomised controlled trial to evaluate the efficacy and safety of an early rule-out pathway. Introducing the pathway into routine clinical practice reduced length of stay by more than three hours and increased the proportion of patients discharged from the emergency department by over 50%”.